New loan signing Denis Suarez alongside Mesut Ozil and Aaron Ramsey were left on the bench, with Emery handling starts to Iwobi, Lichtsteiner and Nacho Monreal.
Pep Guardiola, meanwhile, is starting the game with only three recognized defenders in an attacking formation.
Manchester City starting XI: Ederson, Walker, Laporte, Otamendi, Fernandinho, Gundogan, Silva (C), De Bruyne, Bernardo, Sterling, Aguero.
Subs: Muric, Danilo, Stones, Delph, Sane, Mahrez, Jesus.
Arsenal Starting XI: Leno, Lichtsteiner, Kolasinac, Mustafi, Monreal, Koscielny, Torreira, Guendouzi, Iwobi, Aubameyang, Lacazette.
Subs: Cech, Mavropanos, Elneny, Ramsey, Ozil, Suarez, Nketiah.