Other than Alexandre Lacazette who is suspended, the only players missing for Unai Emery‘s side should be long-term absentees Hector Bellerin, Rob Holding and Danny Welbeck.
Lucas Torreira was sent off at the weekend and will serve a three-match Premier League ban, but is available to feature against Rennes.
Petr Cech will start in goal for the Gunners, returning to the club where he spent three years before moving to Chelsea in 2004.
Arsenal squad vs Rennes:
Cech, Leno; Maitland-Niles, Sokratis, Koscielny, Mustafi, Monreal, Kolasinac; Guendouzi, Torreira, Xhaka, Ramsey, Iwobi, Suarez, Mkhitaryan, Ozil; Aubameyang, Nketiah.