A victory for the Gunners against the Saints would serve as a huge boost for Unai Emery’s side.
Mesut Ozil, ones again, finds himself on the bench for this mouthwatering tie.
Arsenal: Leno, Lichtsteiner, Sokratis, Mustafi, Kolasinac, Torriera, Xhaka, Mkhitaryan, Ramsey, Iwobi, Lacazette.
Sub: Cech, Koscielny, Monreal, Guendouzi, Suarez, Ozil, Aubameyang.
Southampton: Gunn, Valery, Bednarek, Vestergaad, Stephens, Targett, Hojbjerg, Romeu, Ward-Prowse, Armstrong, Redmond.
Subs: McCarthy, Bertrand, Yosida, Slattery, Elyounoussi, Obafemi, Austin.